Düsseldorf, Nordrhein-Westfalen
DIE CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN
Die Charité - Universitätsmedizin Berlin ist eine gemeinsame Einrichtung der Freien Universität Berlin und der Humboldt-Universität zu Berlin. Sie hat als eines der größten Universitätsklinika Europas mit bedeutender Geschichte eine führende Rolle in Forschung, Lehre und Krankenversorgung inne. Aber auch als modernes Unternehmen mit Zertifizierungen im medizinischen, klinischen und im Management-Bereich tritt die Charité hervor.
PhD student (m/f/d) in functional cancer genomics
Campus Benjamin Franklin, Steglitz
Jobcode: 5717 | Work time: part-time | Start date: Ab Januar 2026 | Employment period: limited | Application deadline: 16.12.2025 | Salary group: E13
Working at Charité
We are seeking a highly motivated PhD student (m/f/d) to join our research on functional cancer genomics and therapy resistance at the Charité, Berlin. This DFG-funded position offers an exciting opportunity to contribute to a deeper understanding of cancer origin and treatment resistance by applying cutting edge technologies in an international, vibrant, and collaborative research environment. Our department offers state-of-the-art infrastructure including single-cell genomics/transcriptomics, spectral flow cytometry, proteomics, various imaging techniques, in vivo work, access to patient material and active interaction with clinical departments. You also benefit from numerous interactions with other groups with expertise in cancer biology or immunology, as well as various opportunities for advanced scientific education and training.
Overview of the position
- You will be invovled in the research project dealing with cellular senescence, one of the nature-given safety mechanisms preventing cancer by inhibiting the proliferation of harmful mutated cells. Inactivation of this safety program is necessary for malignant transformation, but how this happens during mutagenesis is not clear. To address this, we study mutational networks of B-cell lymphomas in wild type or genomically senescent-deficient mouse strains. By inducing transposon mutagenesis in healthy B-cells and sequencing the mutation sites in resulting malignant cells, we dissect the driving force of lymphomas and senescence-inactivating mechanisms. We further study how this mutational network evolves under therapy to understand treatment resistance and find novel treatments that overcome it.
- Your responsibilities will be:
- Designing and conducting experiments to detect and evaluate the mutational events leading to B-cell lymphomas
- In-depth characterization of tumor samples using bulk and single-cell analyses, as well as functional assays
- Analyzing and interpreting experimental data, presenting research findings
- Collaborating effectively with a multidisciplinary team of scientists and technicians
What we are looking for
- Master’s degree in cell biology, biotechnology, molecular biology, or related field
- Hands-on experience in cell culture and molecular biology techniques
- Experience in handling experimental mouse models and certified training (FELASA or equivalent) is a plus
- Experience in bioinformatic analyses and/or programming skills is a plus
- Scientific curiosity, proactive working attiude and strong analytical and problem-solving skills
- Fluent command of written and spoken English
Charité offers you
- Highly professional work environment in motivated and interdisciplinary teams
- A future-oriented, varied and demanding position with a high grade of personal responsibility and personal decision making opportunities
- Intercultural team events, well structured onboarding phase with kind team members
- Extensive offers for inhouse training and professional development as well as further qualifications
- Special offers in the areas of shopping, travel and sports
- Bike leasing via "JobRad" possible, bike repair workshop with subsidised price conditions for employees available
- Additional pension program with a company wide pension scheme
- Certification as a family friendly university and company since 2007
- Consideration of personal wishes regarding the weekly working schedule
Information regarding the position
- Paygrade E13 according to TVöD VKA-K. Your job grade depends on your job qualification whereas the experience level depends on the number of working years. The yearly gross salary is hereby provided based on a full time position excluding yearly bonus and additional pay.
- Working time will be 65% (100% = 38,5 hours a week)
- The position is limited until 31.12.2028, as it is tied to the project duration
- 30 days of paid vacation per year
- The application period ends on: 16th December 2025
- Position ID: 5717
Application
Everyone is welcome at the Charité, regardless of age, religion, gender, gender identity, personal orientation, nationality, disability, ethnic or social background. We are committed to equal opportunities and inclusion.
Apply using our online tool and become part of the Charité.
If you have questions, please contact:
jasmin.radenkovic(at)charite.de
You may find further information here
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5717
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