The University Hospital Essen offers first class medical services in the Ruhr metropolis. Every year, 225.000 patients are treated in 30 clinics, 27 institutes and specialized centers. The over 8.000 employees offer medical care with state-of-the-art diagnosis and therapies, which meet highest international standards. Patient care is connected with basic and translational research at an internationally competitive level.
Hemoglobin is best known for its role in oxygen transport in red blood cells. Our preliminary findings indicate that it is also expressed by lung immune cells, where it may contribute to antiviral defense. These findings further suggest that the thrombospondin-1 (TSP-1)/CD47 signaling axis limits hemoglobin expression and its associated antiviral antivity.
The project aims to uncover the molecular mechanisms underlying hemoglobin-mediated antiviral defense and determine how this response is regulated by TSP-1/CD47 signaling. Combining mechanistic studies with in vivo models, we will explore whether targeting this pathway can enhance antiviral immunity while avoiding excessive inflammation and lung tissue damage.
At the Insitute of Medical Microbiology (working group of PD Dr. Torben Knuschke), we are therefore offering the following position, which is fully funded by the German Research Foundation (DFG) and will start on 1 January 2027
Hemoglobin is best known for its role in oxygen transport in red blood cells. Our preliminary findings indicate that it is also expressed by lung immune cells, where it may contribute to antiviral defense. These findings further suggest that the thrombospondin-1 (TSP-1)/CD47 signaling axis limits hemoglobin expression and its associated antiviral antivity.
The project aims to uncover the molecular mechanisms underlying hemoglobin-mediated antiviral defense and determine how this response is regulated by TSP-1/CD47 signaling. Combining mechanistic studies with in vivo models, we will explore whether targeting this pathway can enhance antiviral immunity while avoiding excessive inflammation and lung tissue damage.
At the Insitute of Medical Microbiology (working group of PD Dr. Torben Knuschke), we are therefore offering the following position, which is fully funded by the German Research Foundation (DFG) and will start on 1 January 2027
PhD Position (m/f/d) - Infection Immunology / Virology
Activities and responsibilities
- Perform in vitro and in vivo experiments to characterize the intrinsic and extrinsic (paracrine) funtions of hemoglobin in lung immune and epithelial cells
- Apply molecular biology techniques
- Plan, perform, and analyze therapeutic intervention studies
- Present research findings at national and international conferences and contribute to peer-reviewed publications
- Assist in supervising Bachelor`s/Master`s students
Qualification profile
- A completed Master´s degree (or equivalent) in Biology, Molecular Medicine, Immunology, Biochemistry, or a related field
- Solid background in cell culture and standard molecular biology techniques
- Experience in laboratory animal science (FELASA B) is an advantage
- Strong interest in basic research in Virology/Immunology
- Independent, structured, and team-oriented working-style
- Excellent written and spoken English skills; German language skills are a plus but not required
We offer
- An exciting, methodologically diverse PhD project in an internationally visible research field
- Dedicated supervision of the doctoral project within a cooperative working group with regular seminars
- State-of-the-art laboratory infrastructure at University Hospital Essen
- Interdisciplinary work with colleagues from other departments
- Enrollment into the Graduate School for Biomedical Sciences `BIOME` (https://www.uni-due.de/biome)
- Salary according to the German public sector pay scale (TV-L, E13, 65%), fixed-term for 3 years
- A collegial working environment that encourages independent scientific ideas
- Family-friendly corporate culture
We invite interested applicants to submit their application including a cover letter, CV, two references, academic transcripts, and copies of all university degrees in one pdf file only via email. Only applications that fulfill the formal requirements will be considered!
Contact:
Dr. Annette Eyking-Singer
Scientific Coordinator, Institute of Medical Microbiology, University Hospital Essen, Virchowstr. 179, 45147 Essen, Germany
(https://medizinische-mikrobiologie.uk-essen.de/lehrstuhl-fuer-infektionsimmunologie/)
We use your data exclusively for application purposes in accordance with the applicable dara protection regulations. Further information can be found in the privacy setting on our homepage at: www.uk-essen.de.
Contact:
Dr. Annette Eyking-Singer
Scientific Coordinator, Institute of Medical Microbiology, University Hospital Essen, Virchowstr. 179, 45147 Essen, Germany
(https://medizinische-mikrobiologie.uk-essen.de/lehrstuhl-fuer-infektionsimmunologie/)
We use your data exclusively for application purposes in accordance with the applicable dara protection regulations. Further information can be found in the privacy setting on our homepage at: www.uk-essen.de.
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