clinical research unit CATCH ALL
Department of Internal Medicine II, Section for Special Hematological Diagnostics
The University Medical Center Schleswig-Holstein is one of the largest university hospitals in Europe with more than 80 clinics and institutes. It offers outstanding medical treatment and excellence in research and education with more than 16,000 employees. We provide top research at the interface of medicine, science and technology and maintain research cooperations with universities all over the world.
The Department of Internal Medicine II primarily treats patients with haematological and oncological diseases. The department maintains a large haemato-oncological therapy outpatient clinic. The Section for Special Hematological Diagnostics includes an international multidisciplinary team of medical doctors, biologists and bioinformaticians, with many national and international collaborations. We perform routine multiparametric flow cytometry and molecular genetic diagnostics for hematological malignancies and reference diagnostics for clinical trials and also work on many exciting research projects in the field. Within a DFG-funded Clinical Research Unit CATCH-ALL we are looking for talented PhD student with a high level of commitment, willingness to learn and teamworking skills.
The project focuses on understanding leukemia-specific and immunological mechanisms of MRD persistence and by back-translation of clinical observations and aims to define clinically applicable biomarkers of T-cell fitness in the setting of immunotherapy. In addition, the role of clonal hematopoiesis in leukemogenesis and response to chemo- and immunotherapies will be investigated. Combined genomic and epigenetic analyses at the single cell level will be used to get insights into the role of epigenetics in leukemogenesis in the context of clonal hematopoiesis but also allow lineage tracing to study clonal evolution of ALL and impact of clonal hematopoiesis in distinct immune compartments, including T-cells. Experience with single cell sequencing and multiparametric flow cytometry is advantageous.
Start in our team:
We are looking for professional and competent support to start as soon as possible, limited to four years.
The UKSH has been certified as a family-friendly institution and is committed to further improving the compatibility of work and family life. We support the employment of disabled persons. Persons with disabilities will, with appropriate qualifications and aptitudes, be employed preferentially. The UKSH has set the goal to reach professional equality between men and women. The University aims to increase the number of women among the faculty staff and therefore explicitly encourages the application of female scientists.
Department of Internal Medicine II, Section for Special Hematological Diagnostics
The University Medical Center Schleswig-Holstein is one of the largest university hospitals in Europe with more than 80 clinics and institutes. It offers outstanding medical treatment and excellence in research and education with more than 16,000 employees. We provide top research at the interface of medicine, science and technology and maintain research cooperations with universities all over the world.
The Department of Internal Medicine II primarily treats patients with haematological and oncological diseases. The department maintains a large haemato-oncological therapy outpatient clinic. The Section for Special Hematological Diagnostics includes an international multidisciplinary team of medical doctors, biologists and bioinformaticians, with many national and international collaborations. We perform routine multiparametric flow cytometry and molecular genetic diagnostics for hematological malignancies and reference diagnostics for clinical trials and also work on many exciting research projects in the field. Within a DFG-funded Clinical Research Unit CATCH-ALL we are looking for talented PhD student with a high level of commitment, willingness to learn and teamworking skills.
The project focuses on understanding leukemia-specific and immunological mechanisms of MRD persistence and by back-translation of clinical observations and aims to define clinically applicable biomarkers of T-cell fitness in the setting of immunotherapy. In addition, the role of clonal hematopoiesis in leukemogenesis and response to chemo- and immunotherapies will be investigated. Combined genomic and epigenetic analyses at the single cell level will be used to get insights into the role of epigenetics in leukemogenesis in the context of clonal hematopoiesis but also allow lineage tracing to study clonal evolution of ALL and impact of clonal hematopoiesis in distinct immune compartments, including T-cells. Experience with single cell sequencing and multiparametric flow cytometry is advantageous.
Start in our team:
We are looking for professional and competent support to start as soon as possible, limited to four years.
Research Scientist / PhD position (m/f/d) in experimental hemato-oncology
Activities and responsibilities
- As part of a multi-center collaborative project, you will perform single-cell sequencing, do sorting, quantitative molecular assays and methylation profiling
- You perform T-cell functional assays and correlate functional T-cell readouts with clinical data
- The project will be embedded in a national multicenter treatment study on ALL in adults
Qualification profile
- The call is addressed to scientists in the field of biology / medical life science / computational biology with the appropriate qualifications
- Completed university studies (master / diploma) in a natural science subject or a comparable qualification
- Experience in multicolor flow cytometry and the analysis of high-throughput sequencing data is an advantage
- Experience in the field of hematology is an advantage
- You are a team-oriented person with good communication skills and fluent English and have basic command in German
We offer
- The salary will be based on the German E13 TV-L scale (65%) if terms and conditions under collective bargaining law are fulfilled
- Currently 38.5 hours/ week. Part-time employment may be compatible within the framework of certain working time models
- Many employee discounts on various online platforms and with various companies
- University sports and fitness at a company rate as a balance to work
- You can find more attractive UKSH benefits here: Benefits (uksh.de)
The UKSH has been certified as a family-friendly institution and is committed to further improving the compatibility of work and family life. We support the employment of disabled persons. Persons with disabilities will, with appropriate qualifications and aptitudes, be employed preferentially. The UKSH has set the goal to reach professional equality between men and women. The University aims to increase the number of women among the faculty staff and therefore explicitly encourages the application of female scientists.
For more information visit: jobs.uksh.de | https://www.uksh.de/haematologielabor-kiel
Location: Kiel
Reference number: 27488
Your contact person:
Prof. Dr. Monika Brüggemann (email: email, phone: +49431 500 24980),
Dr. med. Dr. rer. nat. Guranda Chitadze (email)
Recruiter: Jessica Puton, Tel. 0431 500-11191
Location: Kiel
Reference number: 27488
Your contact person:
Prof. Dr. Monika Brüggemann (email: email, phone: +49431 500 24980),
Dr. med. Dr. rer. nat. Guranda Chitadze (email)
Recruiter: Jessica Puton, Tel. 0431 500-11191
Bitte beziehe dich bei deiner Bewerbung auf jobvector
und verwende die folgende Referenznummer:
27488
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