The Clinic for Radiotherapy at the University of Duisburg-Essen Medical School invites applications for a PhD position (65% TV-L) in the Division of Radiation Biology.
The position is funded by the German Federal Ministry of Research, Technology, and Space (BMFTR), as part of a project entitled: “Steps Towards Radiation Protection 2.0: Genome-Wide Analyses of Structural Changes in Cells Following High- and Low-LET Radiation.”The project aims to test next-generation sequencing (NGS) technologies as innovative tools in radiation protection. Ionizing radiation induces DNA damage, the repair of which can lead to structural chromosomal abnormalities and diverse sequence alterations. These genomic alterations can be detected and characterized using next-generation sequencing and possibly developed into radiation-specific genomic “signatures”. Using these technologies, the project seeks to develop practical applications including detection of radiation exposures, dose estimations, and assessment of individual repair capacity and radiosensitivity. The research activities include genome-wide analyses of structural changes induced in the genome by low- and high-LET radiation and the characterization of the specific DNA repair pathways underpinning their formation. The work requires experience in NGS, bioinformatics, q-PCR, and molecular cytogenetics.
The position is funded by the German Federal Ministry of Research, Technology, and Space (BMFTR), as part of a project entitled: “Steps Towards Radiation Protection 2.0: Genome-Wide Analyses of Structural Changes in Cells Following High- and Low-LET Radiation.”The project aims to test next-generation sequencing (NGS) technologies as innovative tools in radiation protection. Ionizing radiation induces DNA damage, the repair of which can lead to structural chromosomal abnormalities and diverse sequence alterations. These genomic alterations can be detected and characterized using next-generation sequencing and possibly developed into radiation-specific genomic “signatures”. Using these technologies, the project seeks to develop practical applications including detection of radiation exposures, dose estimations, and assessment of individual repair capacity and radiosensitivity. The research activities include genome-wide analyses of structural changes induced in the genome by low- and high-LET radiation and the characterization of the specific DNA repair pathways underpinning their formation. The work requires experience in NGS, bioinformatics, q-PCR, and molecular cytogenetics.
PhD Position (all genders) – Radiation Biology and Cancer Research
Activities and responsibilities
- Conduct research in radiation biology.
- Apply NGS and molecular cytogenetic methods for genome-wide analysis.
- Perform bioinformatic evaluation and data integration of structural genomic alterations.
- Present results in national and international conferences and publish research results in peer-reviewed journals.
Qualification profile
- Master’s degree in Cell or Molecular Biology, Biochemistry, Computational Biology, or a related field.
- Practical experience with NGS data analysis and/or cytogenetic techniques.
- Strong interest in cancer biology and radiation oncology.
- Excellent analytical, organizational, and communication skills.
- Ability to work independently and in a team-oriented environment.
- Fluent in spoken and written English.
We offer
- An interdisciplinary research environment with state-of-the-art laboratory facilities.
- Regular supervision and mentoring.
- Competitive salary according to TV-L (65%) and support for professional development.
- Opportunity to contribute to cutting-edge research in DNA repair, radiation protection, and cancer biology.
- Opportunity to take part in lab visits at our collaborating research facilities in Athens, Greece, and at Colorado State University, USA.
- Attractive fringe benefits, including discounted canteen meals, participation in community events, and accommodation in a student dormitory, subject to availability.
The University of Duisburg-Essen is committed to equal opportunity employment. Applications from women are particularly encouraged. When qualifications, competence, and specific achievements are comparable, women will be given equal consideration. Candidates with disabilities who possess equivalent qualifications will be given preference.
Please send your CV, motivation letter, and transcripts of your degrees and other relevant qualifications, in a single PDF file, to Dr. rer. nat. Aashish Soni, Email: email Please include 2-3 letters of recommendation and/or names of individuals to contact for a reference. It is highly desirable to include mentors of B.Sc. and M.Sc. project work.
Please send your CV, motivation letter, and transcripts of your degrees and other relevant qualifications, in a single PDF file, to Dr. rer. nat. Aashish Soni, Email: email Please include 2-3 letters of recommendation and/or names of individuals to contact for a reference. It is highly desirable to include mentors of B.Sc. and M.Sc. project work.
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