Our group at the University Hospital Erlangen is recruiting a highly motivated PhD candidate.
The project “P13 - Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota” is part of the Collaborative Research Centre TRR 417 “Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation”, a major German research consortium (Frankfurt - Freiburg - Erlangen).
The project “P13 - Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota” is part of the Collaborative Research Centre TRR 417 “Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation”, a major German research consortium (Frankfurt - Freiburg - Erlangen).
PhD Position – Colorectal Cancer & Tumor Microenvironment
Activities and responsibilities
The PhD candidate will investigate the impact of the endogenous peptide GPR15L on the tumor microenvironment in colorectal cancer (in particular with regard to T cell recruitment and with regard to effects on the intestinal microbiome) using state-of-the art in vivo and in vitro models along with human samples.
To this end, the candidate will be trained in the following techniques:
To this end, the candidate will be trained in the following techniques:
- Multi-color flow cytometry
- Advanced mouse genetics
- State-of-the-art mouse models of colorectal cancer
- Analysis of omics data
- Organoid culture systems
- Standard molecular biology methods
Qualification profile
Your Profile:
- Completed Master's degree (or equivalent) in immunology, molecular biology, molecular medicine or related disciplines
- Strong interest in translational research
- Excellent written and spoken English
- Structured working style
- Team-oriented mindset (you will work in a working group with more than 15 colleagues and collaborate with several groups associated to the TRR417 consortium)
- Knowledge of basic molecular biology techniques such as IHC, PCR, histology, cell culture or flow cytometry
- Experience in working with mice (Felasa B) and basic knowledge of bioinformatics is advantageous
- Possible starting date: 01.01.2027
We offer
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