Your role in cutting edge research
The German Center for Neurodegenerative Diseases (DZNE) is a globally leading, internationally oriented research institution dedicated to discovering new approaches for the prevention and treatment of neurodegenerative diseases.
Our recent work has uncovered that certain immune pathways can regulate microglial metabolism and the levels of key metabolites, which has a downstream effect on gene transcription and cell function (McManus et al., 2025, Immunity and unpublished findings from the lab). This project will investigate how alterations in metabolism can influence the microglial response associated with neurodegeneration.
Specifically, this project will involve cell culture work using murine and human microglial cells, immune activation assays, and state-of-the-art lab techniques (metabolic assays, flow cytometry or fluorescence imaging, and biochemical techniques, e.g., western blot, quantification assays).
MSc Student (f/m/x) in the Field of Neuroimmunology
Code: 1555/2026/7
full time, fixed-term
Location: Bonn
Your role in detail
We are seeking an enthusiastic and motivated MSc student to conduct research at the interface of immunology and neuroscience, for a MSc thesis or as part of an internship.
The student will be a member of the ‘Translational Neuroimmunology’ research group, led by Dr. Róisín McManus, which is based at the DZNE in Bonn and is also associated with the Institute of Innate Immunity at the University Hospital Bonn, the ImmunoSensation2 Cluster of Excellence and the Collaborative Research Centre “Metaflammation” (SFB 1454).
Our research focuses on understanding how microglia-mediated neuroinflammation contributes to the progression of Alzheimer’s disease. Specifically, we examine how immune signaling and metabolic changes combine to modulate microglial function, affecting disease outcome.
Your profile in cutting edge research
- Currently enrolled at a university and conducting a MSc degree; BSc degree in immunology, neuroscience, biology, a similar discipline
- Previous experience in experimental immunology, neuroscience, or cell metabolism research would be very beneficial
- Hands-on experience in cell culture and biochemistry techniques (protein assays, western blot, and PCR); familiarity in immunohistochemistry or flow cytometry is a plus
- Fluency in English for communicating, writing, and presentation of scientific data
- Strong enthusiasm and motivation for interdisciplinary research
- Excellent problem solving skills and ability to work independently
- Willingness to work in a diverse and interdisciplinary team of international scientists
We Offer
- A feel-good working environment - our Bonn employees enjoy a campus surrounded by greenery with on-site parking and public transport connections as well as our company restaurant
- Personalized onboarding - for a good start to your new professional challenge
- Innovation and internationality - a forward-looking infrastructure, modern laboratory and office equipment, software tools, and the opportunity for international exchange with your colleagues from 65 nations
- Health promotion - through our extensive range of company health programs in cooperation with Sozialwerk.Bund
- Focus on development - training programs tailored to your individual needs and annual HR development meetings for concrete prospects and potential development
- Family-conscious corporate culture - because we know that family is important, we support you with our family service
Interested?
Excellence in research thrives on diverse perspectives and experiences. We stand for a respectful and open culture. We promote equal opportunities, remove barriers, and welcome applications from people across all dimensions of diversity. We particularly welcome applications from people with disabilities.
Interested applicants should submit a cover letter, CV, transcripts, and the contact details for references in one single PDF file. For an internship you will need a letter from your university confirming that it is mandatory as part of your degree program. Only applications submitted via our portal will be accepted. Please refrain from sending your application by e-mail.
Review of applications will begin immediately and continue until the position is filled.
For questions related to the position, please contact Dr. Róisín McManus at roisin.mcmanus(at)dzne.de
Jill Lewandowski
Team HR Recruiting
+49 228 43302-147
Please apply via the apply button.
Application deadline: September 1, 2026
