PhD/Postdoc position in computational biology to elucidate NR2F1 dosage dependent regulatory networks in health and disease (m/f/d)

• Establish computational pipelines for the analysis and integration of single-cell multi-omics data (scRNA-seq, scATAC-seq, Multiome) to reconstruct gene regulatory networks in 3D forebrain dorsal organoids to determine pathophysiological consequences of aberrant NR2F1 dosage
• Design and build an interactive, open-access web platform for visualization and usage of multi-omics datasets
• Integrate newly generated data with in-house and publicly available datasets to interpret results in a robust biological context
• Ensure reproducibility, data management, and documentation of computational workflows in high-performance computing environments
• Collaborate closely with experts in computational biology across the university and affiliated institutes, as well as with experimental researchers (wet lab) in the AG Laugsch, to support accurate data interpretation and integration
• Maintain clear documentation of analyses and computational workflows on eLab and provide regular progress reports and updates
• Actively participate in regular journal clubs and institute meetings. Present findings at lab meetings and international conferences and contribute to manuscripts and grant applications

• Strong background in bioinformatics or computational biology
• Practical experience with omics data pre-processing, pipeline development, and high-performance computing
• Proficiency in R or Python, and shell scripting
• Interest in gene regulation and developmental biology
• Optional previous experience with epigenomic data analysis or gene regulatory network inference
• Ability to work independently and collaboratively in a multidisciplinary environment
• Excellent written and spoken English skills

• Collectively agreed remuneration TV L E13, attractive company pension scheme (VBL)
• 30 days vacation
• Sustainable travel: job ticket
• Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
• Wide range of health, prevention and sports offers
• Possibility to publish scientifically is offered and supported
• Regular team meetings
• Possibility of doctorate

Note: The UKHD is subject to the provisions of the Infection Protection Act. Therefore, a valid proof of measles immunity is required for all persons employed at the UKHD.

The UKHD embraces diversity and values inclusivity.

Regardless of age, gender, personal identity, disability, origin, or religion, we provide everyone with equal opportunities. If a gender is underrepresented in a particular area, we place special emphasis on counteracting this imbalance. Given equal suitability, competence, and professional performance, preference is given to people with severe disabilities when considering applications for open positions.